About Novartis Institute of Biomedical Research: At Novartis Institutes for BioMedical Research (NIBR), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded. It is ultimately the talent of the individual that determines our success, while our state-of-the-art technologies and resources enable these ideas to be realized. NIBR has sites in Cambridge, Massachusetts; Emeryville, CA; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Emeryville location focuses on early drug discovery efforts for the Oncology and Infectious Disease areas and offers a variety of positions in Biology, Chemistry, and functions such as Technology, Patents, Research Sciences and other areas that support our scientific resources. About MAP In NIBR-Emeryville, the MAP (Metabolism and Pharmacokinetics) department is responsible for supporting drug discovery efforts by swiftly delivering a thorough understanding of the pharmacokinetics and metabolic fate of novel chemical entities, rapidly characterizing the ADME properties of medicinal chemistry compounds, and assessing PK/PD relationships of drug discovery candidates. The department supports all aspects of metabolism and pharmacokinetics via in vitro, in silico, ex vivo and in vivo studies to ensure delivery of compounds with good drug-like properties for pre-clinical development. Scientific Associate II/Scientist I, Metabolism and Pharmacokinetics Business Unit: Research Cambridge Division: Novartis Institutes for BioMedical Research (NIBR) Company/Legal Entity: USA Novartis Vaccines and Diagnostics, Inc. Emeryville, CA Job Reference Code: 99922BR About Novartis Institute of Biomedical Research: At Novartis Institutes for BioMedical Research (NIBR), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded. It is ultimately the talent of the individual that determines our success, while our state-of-the-art technologies and resources enable these ideas to be realized. NIBR has sites in Cambridge, Massachusetts; Emeryville, CA; Basel, Switzerland; Horsham, UK; and Shanghai, China. Our Emeryville location focuses on early drug discovery efforts for the Oncology and Infectious Disease areas and offers a variety of positions in Biology, Chemistry, and functions such as Technology, Patents, Research Sciences and other areas that support our scientific resources. About MAP In NIBR-Emeryville, the MAP (Metabolism and Pharmacokinetics) department is responsible for supporting drug discovery efforts by swiftly delivering a thorough understanding of the pharmacokinetics and metabolic fate of novel chemical entities, rapidly characterizing the ADME properties of medicinal chemistry compounds, and assessing PK/PD relationships of drug discovery candidates. The department supports all aspects of metabolism and pharmacokinetics via in vitro, in silico, ex vivo and in vivo studies to ensure delivery of compounds with good drug-like properties for pre-clinical development. About the position: The bioanalytical group in MAP is seeking an individual to assist in developing LC/MS/MS assays for the quantitation of drugs and their metabolites in biological matrices. The successful candidate will also be responsible for sample analysis, data review, project tracking and report generation. In addition, this individual will conduct metabolite identification experiments using LC/MS/MS in support of the discovery of small molecule drugs. This successful candidate will also participate in MALDI imaging mass spectrometry analysis of small molecule drugs and their metabolites in rodent tissue sections. • Bachelor or Masters degree in Biochemistry, Biology, Chemistry or related discipline with at least 5 yrs of laboratory experience in drug metabolism, preferably within the pharmaceutical or biotechnology industry. • Experience developing bioanalytical LC/MS/MS methods for the quantitation of drugs and their metabolites in support of drug discovery. • Proficiency working with 96-well laboratory automation platforms. • Experience working with other high-throughput in vitro ADME profiling assays is desirable. • Experience with tissue preparation for MALDI Imaging MS is a plus. • A good understanding of the underlying principles of drug metabolism, pharmacokinetics and analytical chemistry is essential. • Demonstrated skills in bringing projects to completion within specified timelines. • Strong written and verbal communication skills are essential, along with the ability to work effectively in teams.